Interferon alfa-2b was produced by the Havana-based Genetic Engineering and Biotechnology Center and over the years has been used for diseases from dengue fever to Hepatitis and HIV. Not all dosage forms and strengths are appropriate for all indications; refer to product labeling for details. Interferon alfa-2b injection is used to treat a number of conditions. Interferon alfa-2b may not cure hepatitis B or hepatitis C or prevent you from developing complications from these infections such as cirrhosis (scarring) of the liver, liver failure, or liver cancer. Endocrine Disorders. Studies support the use of oral human-interferon in cats for its immunomodulatory properties. It is a possible treatment for a number of different types of cancer such as: kidney cancer (renal cell cancer) melanoma; multiple myeloma; some types of leukaemia; some neuroendocrine tumours (NETs) non-Hodgkin lymphoma The first one was Beta Interferon in Japan, and the second one was the family of Alpha Interferon by Genetec in California, according to the Cuban doctor. Interferon alpha is strongly antiviral in its higher doses and is a more general modulator of the immune response in lower (“dilute”) doses. Interferon treatments have been studied against coronaviruses including MERS-CoV, SARS-Cov-1 and now SARS-CoV-2 (the causative agent … Many clinicians also use the low dose oral protocol to treat cats with FeLV and FIP with the goal of improving clinical signs and q… The study identified female sex, a dose of interferon alfa above 15 MU/week, and naive patients as independent susceptibility factors for premature withdrawal. Infrequently, patients receiving INTRON A therapy developed thyroid abnormalities, either hypothyroid or hyperthyroid. To treat CML, this drug is most often given as a daily injection (shot) under the skin. Interferon alpha is currently recommended as an option for first-line therapy for individuals with essential thrombocythaemia or polycythaemia vera in whom cytoreduction is indicated. Interferon was once the best treatment for CML, but now, the tyrosine kinase inhibitors are the mainstay of treatment and interferon is rarely used. Interferon alfa-2b treatment should be discontinued in patients who develop new or worsening ophthalmologic disorders. Topical interferon alpha-2b (IFN-α2b) is of particular interest because of its apparent efficacy and low toxicity. Interferon alfa (IntronA, Roferon-A) Interferon alfa is also called by its brand names IntronA and Roferon-A. 22. O'Duffy J D, Calamia K, Cohen S. et al Interferon‐alpha treatment of Behcet's disease. We describe here the effects of treatment with interferon (IFN)-α2b in a cohort of confirmed COVID-19 cases in Wuhan, China. Interferon alfa-2b is an antiviral or antineoplastic drug. or a combination of IFN-α2b plus arbidol. The therapy mainly consists of stimulating the immune system to help it do its job more effectively. This is a type of treatment that mobilizes the body's immune system to fight cancer. Arch Dermatol 1998 134 1010–1016.1016 . It also may not prevent the spread of hepatiti… It was developed at Biogen, and ultimately marketed by Schering-Plough under the trade name Intron-A. Rintatolimod is double stranded ribonucleic acid (RNA) designed to mimic viral infection by stimulating immune pathways that … Human interferon alpha is used in cats to treat FeLV, FIV, FIP, FHV-1 and a variety of dermatologic conditions. Recombinant interferon alfa-2b is also being studied in the treatment of other types of cancer and other conditions. Interferon alpha has proven useful in the treatment of chronic hepatitis B or C, genital warts, and for certain cancers including malignant melanoma, Kaposi's sarcoma associated with AIDS, and follicular lymphoma. However, heightened levels of serum interferon alpha and expression of interferon response genes are common in lupus patients. . Work in 2006 with FIV affected cats showed that the published low dose oral protocol improved both clinical signs and survival times, although there was no decrease in viral load. J Rheumatol 1998 25 1938–1944.1944 . It is recommended as one of the second-line options in patients who are refractory or intolerant to first-line hydroxycarbamide. The findings, researchers said, showed promise for interferon-alpha-2b -- which has been used against hepatitis and some forms of cancer, including melanoma -- as a … Interferon alfa-2b has the same mechanism of action as the natural form of interferon that is secreted by white blood cells in response to a viral infection. It activates immune responses that help to clear viral infection. . 1. Interferon alfa-2b mechanism of action. Interferon alfa is used for intralesional treatment of external anogenital warts and condyloma acuminatum. The U.S. Food and Drug Administration (FDA) … ), arbidol (200 mg t.i.d.) Interferon alfa-2b works to treat hepatitis C virus (HCV) and hepatitis B virus (HBV) by decreasing the amount virus in the body. Original Article Treatment of Adult T-Cell Leukemia-Lymphoma with Zidovudine and Interferon Alfa O. Hermine and Others Editorial Alcohol and Blood Pressure — A Drink a Day . The pleiotropic cytokine interferon alpha is involved in multiple aspects of lupus etiology and pathogenesis. More About Recombinant Interferon Alfa-2b It is used as adjuvant therapy in adults who have had surgery and have a high risk of recurrent cancer. 23. That said, proof of effectiveness, especially with the diluted doses, is lacking in veterinary patients and i ts use should be considered investigational . Immunotherapy is treatment that stimulates the body's immune system to detect and kill cancer cells. Both forms bind to the cell surface receptor to activate enzymes that have antiviral, antiproliferative, and immune-modifying properties. or a combination of IFN-α2b plus arbidol. Interferon alfa-2b is in a class of medications called immunomodulators. It is injected into the base of each wart, preferably via a … We describe here the effects of treatment with interferon (IFN)-α2b in a cohort of confirmed COVID-19 cases in Wuhan, China. Hepatitis B. Interferon alpha-2b is the form of the drug that works against chronic viral hepatitis B infection. Interferon, an immune system chemical that helps the body fend off viruses, is being tested against the coronavirus (vials of the drug seen in production here). They work by helping the body fight the infections. Why are Interferon Alphas prescribed? One use for interferon alpha is the treatment of polycythemia vera. The mechanism by which INTRON A may alter thyroid status is unknown. Interferon alphas are used to treat leukemia, melanoma, non-Hodgkin's lymphoma, Kaposi's Sarcoma, hepatitis C, hepatitis B, and HPV. More information: Qiong Zhou et al, Interferon-α2b Treatment for COVID-19, Frontiers in Immunology (2020).DOI: 10.3389/fimmu.2020.01061 Interferon-alpha is the type most often used in treating chronic myeloid leukemia (CML). How Interferon Alfa Works: Interferon alfa belongs to the category of therapies called biologic response modifiers (BRM), also called immunotherapy. It is a recombinant form of the protein Interferon alpha-2 that was originally sequenced and produced recombinantly in E. coli in the laboratory of Charles Weissmann at the University of Zurich, in 1980. Interferon alpha is a protein important for defense against viruses. Zouboulis C C, Orfanos C E. Treatment of Adamantiades–Behcet disease with systemic interferon alfa. While standard interferon with/without nucleos(t)ide analogues were reported to be inferior to pegylated interferon (peginterferon) as HDV treatment according to few randomized clinical trials. In this uncontrolled, exploratory study, 77 adults hospitalized with confirmed COVID-19 were treated with either nebulized IFN-α2b (5 mU b.i.d. In a retrospective analysis of 441 consecutive patients treated with interferon alfa and ribavirin, 25% of patients discontinued treatment because of adverse reactions [21]. Interferon alpha-2B is an Effective Treatment Option for Treatment of Peyronie’s Disease Regardless of Plaque Location by Alex Shteynshlyuger MD If you have any questions, to schedule a consultation , please contact us or call/text: 1-646-663-4050 . R.G. In this uncontrolled, exploratory study, 77 adults hospitalized with confirmed COVID-19 were treated with either nebulized IFN-α2b (5 mU b.i.d. AIDS-related Kaposi sarcoma: IM, SubQ: 30 million units/m23 times a week; continue until disease progression or until maxi… Interferon (Intron® A or Sylatron™) Adjuvant therapy is secondary cancer treatment, given after primary treatment with surgery, to help delay or prevent the recurrence of cancer. This meta-analysis will summarize the results of studies on the effectiveness of peginterferon as HDV treatment regimen. Consider premedication with acetaminophen prior to administration to reduce the incidence of some adverse reactions. ), arbidol (200 mg t.i.d.) 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